Lokey Research Group
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News

October 2017
New paper summarizing the results of our collaboration with Pfizer and Circle Pharma, and one of our first examples of a cell-permeable cyclic peptide with biological activity! Discovery of potent and orally bioavailable macrocyclic peptide-peptoid hybrid CXCR7 modulators. in J.Med Chem! Congratulations to all authors and contributors!

August 2017
Scott is off to Copenhagen to give a seminar at the 63rd Benzon Symposium – New Paradigms of Protein Engineering – Applications in Modern Medicine.

July 2017
Welcome Grant Koch and Justin Faris, incoming first year grad students. It’s been great having you in the lab this summer!

June 2017
Congratulations to Matt for the recent publication of his review, Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets in Current Opinion in Chemical Biology.

The Lokey group goes to the American Peptides Symposium in Whistler!

May 2017
Congratulations to Cam and co-authors for another publication, Retrospective analysis of natural products provides insights for future discovery trends, in PNAs.

April 2017
Lokey group goes to the Drug Discovery conference in San Diego

Congratulations to Tori for receiving the Unicorn Award a.k.a. The NSF Fellowship!!

March 2017
Cam and Josh become doctors at the very same time. Congratulations for back-to-back PhDs! We wish them all the luck with a strong wind at their backs as they set up their new venture, Unnatural Products, Inc.!

Febuary 2017
Congratulations to Cam and co-authors for this nice perspective, "How Big is Too Big for Cell Permeability", in J. Med Chem from a leader in the field, Jan Kihlberg.

January 2017
Congratulations to Cameron Pye and co-authors for their recent publication in J. Med Chem!

October 2016
Congratulations to Aki and co-authors for their recent publication in J. Med Chem!

Hilarious Lokey Lab Game of Thrones Halloween!

September 2016
Lokey poster presenters amongst the Redwood trees at the UCSC Chemistry Retreat. Congrats, to Victoria Klein who won 3rd place for the poster competition!

August 2016
Congratulations to our Undgraduates: Shero Lao, Daniel Ramos, and Edwin Naranjo who presented their posters at the 2016 UCSC Sciences Summer Research Symposium.

June 2016
Congratulations to Josh and co-authors for their recent publication in ACS Med Chem Lett, with many thanks to our collaborators at Lilly for making this work possible.

New Group Members! Colin Kelly, Victoria Klein, Ryan Noland, and Tannia Lau

May 2016
Congratulations to Dustin for defending his thesis and for graduating with his Ph.D.! Now working at Two Pore Guys.

October 2015
Lokey group wins "Best theatrical rendition of a cell permeable cyclic peptide" at the departmental Halloween party.

Congratulations to Andy and co-authors for "going out on a limb" with their recent paper in J. Med. Chem. Very nice work!

August 2015
Congratulations to Dr. Andy Bockus for earning his PhD! Andy is headed to San Antonio to begin his post-doc training with Adam Urbach at Trinity University. We'll miss you Andy!

June-July 2015
Josh's paper was recommended by Faculty of 1000.

Congratulations to Chris Ahlbach and co-authors for publication of their paper in Future Medicinal Chemistry!

May 2015
Congratulations to Chris Ahlbach for winning the Chancellor's award for excellence in undergraduate research! See his upcoming paper in Future Medicinal Chemistry.

Andy's paper was recommended by Faculty of 1000.

Congratulations to Andy for getting his paper accepted into J. Med. Chem. and surviving to tell about it!

January 2015
Will's paper was recommended by Faculty of 1000.

December 2014
Congratulations to Will Hewitt for graduating with his PhD and taking up a new post-doc position in the Chemical Biology Laboratory at the NCI in Jay Schneekloth's group. We'll miss you, Will!

Congratulations to Will Hewitt and co-authors for acceptance of their article in JACS, Cell-permeable cyclic peptides from synthetic libraries inspired by natural products.

Welcome to PBSE student Cat McCaughey for a fun-filled rotation working on the synthesis of antibiotic depsipeptides!

November 2014
Congratulations to Josh Schwochert for publication in Organic Letters!. Click here to view the full list of our publications.

October 2014
Welcome to our two newest lab members, visiting scientist Dr. Akihiro Furukawa, Associate Senior Researcher New Modality Research Laboratories, Daiichi-Sankyo Co., Ltd., and Dr. Matthew Naylor, post-doctoral researcher from Princeton and recipient of the Lilly Innovation Fellowship Award (LIFA).

September 2014
Congratulations to Dustin Wride, for publication in Molecular BioSystems! Click here to view the full list of our publications.

May 2014
Welcome Chad Townsend, newest member to the Lokey Research Group!

June 2013
Scott Lokey has been profiled by International Innovation. Check it out here!

April 2013
Our research has been highlited inside this month's issue of SciBX!

February 13, 2013
Our paper has been accepted for publication in Current Topics in Medicinal Chemistry. Check out this and other publications with the link above.

September 28, 2012
New Job! After a productive year as a postdoc with the Lokey Group, Terra Haddad has accepted a job as SOP Specialist with UCSC EH&S. Way to go Terra!

September 27, 2012
Art Rand and Chelsea Gustafson start graduate school today! Good Luck!

August 16, 2012
New Paper! Art Rand's paper titled "Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance " was accepted to MedChemComm.

June 2012
Graduation Time! Tina White graduated with her Ph.D. in chemistry this June, and has been offered a job at Genentech. Way to go Tina!

June 2012
New group members! Cameron Pye, Josh Schwochert and Will Hewitt have officially joined the Lokey Research Group. Welcome!


Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets
Matt_CurrOpin


Retrospective analysis of natural products provides insights for future discovery trends
Cpye_PNAs


Lokey Group Representing at the Drug Discovery Conference in San Diego
DrugDiscovery_2017


Tori is Awarded the NSF!
Tori_NSF


Back to back PhDs! Josh and Cam!
JoshCamPhD


Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules
Cpye_JmedChem


Halloween 2016, Game of Thrones
2016Halloween


Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry
Aki_JmedChem


2016 Chemistry Retreat
ChemRetreat


2016 Undergraduate Summer Research Symposium
Undergradposters


Stereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides
Josh_ACSMedChemLett


Halloween 2015, Lokey Cyclosporin
Halloween


Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues.
WillImage


Phenotype-Guided Natural Products Discovery Using Cytological Profiling
WillImage


Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides
WillImage


Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products
AndyImage


Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired by Natural Products
WillImage


Revisiting N-to-O Acyl Shift for Synthesis of Natural Product-like Cyclic Depsipeptides
Josh_OrgLett1


Confirmation of the cellular targets of benomyl and rapamycin using next-generation sequencing of resistant mutants in S. cerevisiae
DustinImage


On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
TinaImage


Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance
MedChemCommImage

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