Lokey Research Group
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News

May 2018
Congratulations to Lokey lab graduate Josh Schwochert for co-first author publication of a paper in collaboration with Dean Tantillo’s group at UC Davis. Fantastic job, Josh and Nhu, on the development of a new method for NMR- and QM-based determination of solution conformations of cyclic peptides! Using 1H and 13C NMR chemical shifts to determine cyclic peptide conformations: a combined molecular dynamics and quantum mechanics approach in Physical Chemistry Chemical Physics.

18th Annual Joseph F. Bunnett Symposium
Congratulations Colin and Quinn for your well deserved chemistry awards!

February 2018
Congratulations to Chad Townsend for his publication, Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry in Bioorganic and Medicinal Chemistry

December 2017
Congratulations to Josh and Andy for the publication of two new book chapters from the Lokey lab:

Bockus, AT and Lokey, RS, Bioactive and Membrane-Permeable Cyclic Peptide Natural Products. in the book Practical Medicinal Chemistry with Macrocycles: Design, Synthesis, and Case Studies (Wiley)

Schwochert, J and Lokey RS, Experimental and Computational Approaches to the Study of Macrocycle Conformations in Solution in the book Experimental and Computational Approaches to the Study of Macrocycle Conformations in Solution (Royal Society of Chemistry).

October 2017
New paper summarizing the results of our collaboration with Pfizer and Circle Pharma, and one of our first examples of a cell-permeable cyclic peptide with biological activity! Discovery of potent and orally bioavailable macrocyclic peptide-peptoid hybrid CXCR7 modulators. in J.Med Chem! Congratulations to all authors and contributors!

The Lokey Group WINS the Halloween Costume Contest!

August 2017
Scott is off to Copenhagen to give a seminar at the 63rd Benzon Symposium – New Paradigms of Protein Engineering – Applications in Modern Medicine.

July 2017
Welcome Grant Koch and Justin Faris, incoming first year grad students. It’s been great having you in the lab this summer!

June 2017
Congratulations to Matt for the recent publication of his review, Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets in Current Opinion in Chemical Biology.

Congratulations to Hahn, Josh, Shero, Tannia and co-authors for their recent publication in Antimicrobial Agents and Chemotherapeutics! Synthetic Cyclic Peptomers as Type III Secretion System Inhibitors.. The first report from our exciting collaboration with the Auerbuch-Stone group!

The Lokey group goes to the American Peptides Symposium in Whistler!

May 2017
Congratulations to Cam and co-authors for another publication, Retrospective analysis of natural products provides insights for future discovery trends, in PNAs.

April 2017
Lokey group goes to the Drug Discovery conference in San Diego

Congratulations to Tori for receiving the Unicorn Award a.k.a. The NSF Fellowship!!

March 2017
Cam and Josh become doctors at the very same time. Congratulations for back-to-back PhDs! We wish them all the luck with a strong wind at their backs as they set up their new venture, Unnatural Products, Inc.!

Febuary 2017
Congratulations to Cam and co-authors for this nice perspective, "How Big is Too Big for Cell Permeability", in J. Med Chem from a leader in the field, Jan Kihlberg.

January 2017
Congratulations to Cameron Pye and co-authors for their recent publication in J. Med Chem! Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules

October 2016
Congratulations to Aki and co-authors for their recent publication in J. Med Chem! Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry

Hilarious Lokey Lab Game of Thrones Halloween!

September 2016
Lokey poster presenters amongst the Redwood trees at the UCSC Chemistry Retreat. Congrats, to Victoria Klein who won 3rd place for the poster competition!

August 2016
Congratulations to our Undgraduates: Shero Lao, Daniel Ramos, and Edwin Naranjo who presented their posters at the 2016 UCSC Sciences Summer Research Symposium.

June 2016
Congratulations to Josh and co-authors for their recent publication in ACS Med Chem Letter! Stereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides, with many thanks to our collaborators at Lilly for making this work possible.

New Group Members! Colin Kelly, Victoria Klein, Ryan Noland, and Tannia Lau

May 2016
Congratulations to Dustin for defending his thesis and for graduating with his Ph.D.! Now working at Two Pore Guys.

October 2015
Lokey group wins "Best theatrical rendition of a cell permeable cyclic peptide" at the departmental Halloween party.

Congratulations to Andy and co-authors for "going out on a limb" with their recent paper in J. Med. Chem. Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues. Very nice work!

August 2015
Congratulations to Dr. Andy Bockus for earning his PhD! Andy is headed to San Antonio to begin his post-doc training with Adam Urbach at Trinity University. We'll miss you Andy!

June-July 2015
Josh's paper was recommended by Faculty of 1000.

Congratulations to Chris Ahlbach and co-authors for publication of their paper in Future Medicinal Chemistry!

May 2015
Congratulations to Chris Ahlbach for winning the Chancellor's award for excellence in undergraduate research! See his upcoming paper in Future Medicinal Chemistry.

Andy's paper was recommended by Faculty of 1000.

Congratulations to Andy for getting his paper accepted into J. Med. Chem. and surviving to tell about it!

January 2015
Will's paper was recommended by Faculty of 1000.

December 2014
Congratulations to Will Hewitt for graduating with his PhD and taking up a new post-doc position in the Chemical Biology Laboratory at the NCI in Jay Schneekloth's group. We'll miss you, Will!

Congratulations to Will Hewitt and co-authors for acceptance of their article in JACS, Cell-permeable cyclic peptides from synthetic libraries inspired by natural products.

Welcome to PBSE student Cat McCaughey for a fun-filled rotation working on the synthesis of antibiotic depsipeptides!

November 2014
Congratulations to Josh Schwochert for publication in Organic Letters!. Click here to view the full list of our publications.

October 2014
Welcome to our two newest lab members, visiting scientist Dr. Akihiro Furukawa, Associate Senior Researcher New Modality Research Laboratories, Daiichi-Sankyo Co., Ltd., and Dr. Matthew Naylor, post-doctoral researcher from Princeton and recipient of the Lilly Innovation Fellowship Award (LIFA).

September 2014
Congratulations to Dustin Wride, for publication in Molecular BioSystems! Click here to view the full list of our publications.

May 2014
Welcome Chad Townsend, newest member to the Lokey Research Group!

June 2013
Scott Lokey has been profiled by International Innovation. Check it out here!

April 2013
Our research has been highlited inside this month's issue of SciBX!

February 13, 2013
Our paper has been accepted for publication in Current Topics in Medicinal Chemistry. Check out this and other publications with the link above.

September 28, 2012
New Job! After a productive year as a postdoc with the Lokey Group, Terra Haddad has accepted a job as SOP Specialist with UCSC EH&S. Way to go Terra!

September 27, 2012
Art Rand and Chelsea Gustafson start graduate school today! Good Luck!

August 16, 2012
New Paper! Art Rand's paper titled "Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance " was accepted to MedChemComm.

June 2012
Graduation Time! Tina White graduated with her Ph.D. in chemistry this June, and has been offered a job at Genentech. Way to go Tina!

June 2012
New group members! Cameron Pye, Josh Schwochert and Will Hewitt have officially joined the Lokey Research Group. Welcome!


Using 1H and 13C NMR chemical shifts to determine cyclic peptide conformations: a combined molecular dynamics and quantum mechanics approach.

Josh_PhysicalChemChemPhysics

18th Annual Joseph F. Bunnett Symposium with guest speaker Dr. Samuel Gellman and Lokey Lab award winners Colin and Quinn.

2018BunnettAwards

Lokey Lab sharing knowledge at the 2018 Chemistry Drug Discovery Conference in San Diego

2018ChemDrugDisConference

Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry

Chad_bioorgmedchem

Lokey Lab Publishes Two New Book Chapters

WIley_RSC_BookChapters201

2017 Halloween Costume WINNERS!!!! Minions strike back!

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Discovery of potent and orally bioavailable macrocyclic peptide-peptoid hybrid CXCR7 modculators

Boehm_Jmedchem

Cyclic peptide natural products chart the frontier of oral bioavailability in the pursuit of undruggable targets

Matt_CurrOpin

Synthetic Cyclic Peptomers as Type III Secretion System Inhibitors.

Hahn_AntimicroChemoAgents

Retrospective analysis of natural products provides insights for future discovery trends

Cpye_PNAs

Lokey Group Representing at the Drug Discovery Conference in San Diego

DrugDiscovery_2017

Tori is Awarded the NSF!

Tori_NSF

Back to back PhDs! Josh and Cam!

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Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules

Cpye_JmedChem

Halloween 2016, Game of Thrones

2016Halloween

Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry

Aki_JmedChem

2016 Chemistry Retreat

ChemRetreat

2016 Undergraduate Summer Research Symposium

Undergradposters

Stereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides

Josh_ACSMedChemLett

Halloween 2015, Lokey Cyclosporin

Halloween

Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues.

WillImage

Phenotype-Guided Natural Products Discovery Using Cytological Profiling

WillImage

Peptide to Peptoid Substitutions Increase Cell Permeability in Cyclic Hexapeptides

WillImage

Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products

AndyImage

Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired by Natural Products

WillImage

Revisiting N-to-O Acyl Shift for Synthesis of Natural Product-like Cyclic Depsipeptides

Josh_OrgLett1

Confirmation of the cellular targets of benomyl and rapamycin using next-generation sequencing of resistant mutants in S. cerevisiae

DustinImage

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

TinaImage

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance

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